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Prolia recall?
Skin problems may occur after receiving Prolia®. Prolia is a medicine that may affect your immune system. Recalls, Market Withdrawals and Safety Alerts;. It is unknown if the long-term use of denosumab time may. Manufacturer customer service or other non-safety recall campaigns. Consequently, the Prolia recall led to the filing of a class-action lawsuit. So don’t put off having your dental work done for the very remote chance of having this happen. Prolia is approved and marketed in over 80 countries worldwide The discovery of significant problems with a product similar to one of our products that implicate an entire class of products. General Mills is voluntarily recalling all-purpose flour that may contain salmonella. If you or someone you love were given the prescription medication Prolia or has been diagnosed with osteoporosis, here's everything you. I started Prolia in January. Denosumab is licensed for the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. Skin problems may occur after receiving Prolia®. We all know that having a good memory is important for success in life, but do you know how your memory measures up? Take this quick memory test to find out. That counteracts the shift in estrogen levels that post-menopausal women experience, reducing the issues of bone loss that occur with this diagnosis. Registering your appliance not only ensures that you receive any safety or recall notificati. The "Warnings and Precautions" section of the denosumab labeling was updated between April 2019 and February 2020 include that the. Jan 11, 2021 · Prolia is the brand name for the generic drug denosumab. Most patients do not pay the list price. Long-term use of Prolia ® has been studied for up to 10 years in the pivotal phase 3 fracture trial and open-label extension 5-7. Skin problems such as inflammation of your skin (dermatitis), rash, and eczema may happen if you take Prolia. Each 1 mL single-use prefilled syringe of Prolia contains 60 mg denosumab (60 mg/mL solution), 4. O) drug Prolia to treat bone loss as it increases … The FDA said Amgen’s Prolia may lead to low levels of calcium, or hypocalcemia. It is a treatment for secondary bone cancer (cancer that has spread to the bones). Vehicle recalls can range from the serious to the minor, but either way, it’s important to know what’s going on with your car. Denosumab (XGEVA®, Prolia®) Denosumab (XGEVA®, Prolia®) is used to strengthen and protect the bones from the effect of cancer or cancer treatment. It can help to strengthen bones, making them less likely to break. As a responsible vehicle owner, it is crucial to stay updated on any recalls or safety issues that may affect your vehicle. Australian regulators warn that the side effects of the bone drugs Prolia and Xgeva can result in abnormal heart rhythms. Denosumab (Prolia) is recommended for people at high risk for fractures for whom other bone-loss treatments were ineffective or had intolerable side effects. Check with your doctor right away if you have blistering, crusting, irritation, itching, or reddening of the skin, cracked, dry, or scaly skin, rash, or swollen skin. Skin problems • Skin problems may happen if you take Prolia® • Symptoms of skin problems include: – Dermatitis (redness, itching) – Eczema (leathery dry skin, blisters that ooze or become crusty, skin peeling) Thigh bone fracture Call your doctor right away if you think you may be having any of these side effects. The FDA has warned patients using Amgen's osteoporosis drug Prolia that stopping treatment could lead to an increased risk of spinal fractures. Use of Amgen's osteoporosis drug Prolia by those with advanced CKD can increase the risk of calcium loss in the blood, according to the FDA. It has a list price $1,736 For commercially insured patients, the Amgen SupportPlus Co-Pay Program offer Prolia for as little as $25 dose An additional seven lots of Treprostinil are affected on top of last month's recall of one lot FDA Approves Pen. Denosumab (XGEVA®, Prolia®) Denosumab (XGEVA®, Prolia®) is used to strengthen and protect the bones from the effect of cancer or cancer treatment. The most common side effects of Prolia® in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). I had to stop the Prolia because I needed four teeth removed within 6 months after trying root canals that failed and then had two dental implants. Endocrinology > Osteoporosis Study Quantifies Dental, Jaw Risks With Denosumab — 10-year data suggest oral issues common. The most common side effects of Prolia® in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection. Now, a consumer watchdog said the warnings haven. Denosumab is a type of targeted drug called a monoclonal antibody. difficulty with eating. Personal injury lawyers recently filed a Prolia class-action lawsuit against Amgen, the manufacturer of the drug. The New Zealand data sheet includes warnings on the risk of skin infections, such as cellulitis [ 1 ]. Your doctor may tell you to see your dentist before you start Prolia. At that time, questions remained regarding the long-term safety and efficacy of this receptor activator of nuclear factor. Denosumab, a bone anti-resorptive medication, treats osteoporosis and various bone-related disorders. If you own a Subaru or are considering purchasing one, it’s important to stay informed about any potential recalls that may affect your vehicle. has been demonstrated. In patients with advanced chronic kidney disease, treatment with Prolia (denosumab) increases the risk of severe hypocalcemia, according to an updated FDA safety alert. The risk is greater with decreased kidney function, and health care providers are advised to use cautiously in these cases. My body couldn't handle it. Talk to your insurance provider. Prolia's cost may depend on factors such as your dosage, whether you have health insurance. RELATED: Amgen's bone drug Prolia nabs data for new use on its way to. The osteoporosis drug's black box warning follows an FDA review of Centers for Medicare & Medicaid Services. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. Key differences between Evenity and Prolia. Your doctor may tell you to see your dentist before you start Prolia. Prolia Recall/Black Box Warning Information: Prolia does not carry any black box warnings and has not been associated with any recalls. Another common osteoporosis medication is denosumab (Prolia, Xgeva). It's also marketed as an alternative. Prolia (denosumab) works well to strengthen your bones. Immediately after the extraction it’s important to keep biting on the gauze for 20 minutes or longer to ensure it clots well. Prolia's cost may depend on factors such as your dosage, whether you have health insurance. Prolia ® is proven to help strengthen bones and reduce spine fracture risk by 68% with 1 shot every 6 months In a 3-year study, women not treated with Prolia ® had more new spine fractures (7. Denosumab isn’t usually given as a first treatment for osteoporosis. It is important for you to practice good mouth care during treatment with Prolia. Reclast is infused into your veins once or twice a year, while Prolia is administered as an injection under your skin every 6 months. May 11, 2012 · By all three methods, patients taking denosumab 60 mg every 4 weeks had a two-to-three-fold greater risk of serious adverse cutaneous events: OR 2001 PRR 2001 EBGM 2001. Check out the step-by-step instructions on how to recall an email in Outlook. Prolia (denosumab) works well to strengthen your bones. The most common side effects of Prolia® in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and. It helps stop the development of bone-removing cells before they can reach and damage the bone. Skin problems may occur after receiving Prolia®. The FDA also required Amgen to. People who have a weakened immune system or take medicines that. see through under wear The FDA has just announced plans for a black box warning that involves Prolia (denosumab) and very low calcium levels ( hypocalcemia ). difficulty with eating. Sep 21, 2023 · Common Prolia side effects (those that were experienced by at least 5% of people in clinical) include: Back pain. Prolia is a brand (trade) name for denosumab which may be used to treat osteoporosis Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. Your doctor should examine your mouth before you start Prolia. After 3 to 5 years, your healthcare provider may stop your Reclast prescription and prescribe a different osteoporosis treatment. Many studies have shown that a drug holiday significantly reduces the. Denosumab isn’t usually given as a first treatment for osteoporosis. See Full PI & Safety Info. Pancreatitis has been reported with Prolia®. It helps to strengthen the bones and prevent fractures for some types of cancer. MedWatch Safety Alerts are distributed by the FDA and published by Drugs Following is a list of possible medication recalls, market withdrawals, alerts and warnings Nov 22, 2022. Maybe they were on to something. News, stories, photos, videos and more. Prolia is administered by injection once every six months. Skin problems • Skin problems may happen if you take Prolia® • Symptoms of skin problems include: – Dermatitis (redness, itching) – Eczema (leathery dry skin, blisters that ooze or become crusty, skin peeling) Thigh bone fracture Call your doctor right away if you think you may be having any of these side effects. For Osteoporosis "Prolia, for me, it was a nightmare. Product recalls can be a nightmare for both consumers and manufacturers. wegovy contraindications This past June 1st, the FDA approved Prolia ™ (denosumab), a brand new twice-yearly injectable osteoporosis drug by Amgen. Australian regulators warn that the side effects of the bone drugs Prolia and Xgeva can result in abnormal heart rhythms. Denosumab 60 mg subcutaneously every 6 months is an approved treatment for women with PMO who are at high risk for fracture. Medication Guide. Jun 27, 2023 · It’s not fatal and can be repaired surgically. I would like to invite @ritafarmer, @mabel343, @kenzreggie, @bonnieh218, and @tessie to share any side-effects they, or a loved one, had or didn't have while taking Prolia. Recent headlines have highlighted numerous cases of products being recalled du. Manufacturer customer service or other non-safety recall campaigns. It's given as an injection under the skin by a healthcare professional (HCP), typically at their clinic or office. 7% sorbitol, 17 mM acetate, 0. However, this medication can cause a decrease in calcium (hypocalcemia), sometimes severely. He is an expert on osteoporosis and all of the osteo meds. Official answercom. For Osteoporosis "Prolia, for me, it was a nightmare. Jan 19, 2024 · Prolia was initially approved in 2010 for postmenopausal women. Prolia can cause many serious side effects. Immediately after the extraction it’s important to keep biting on the gauze for 20 minutes or longer to ensure it clots well. Prolia works by turning off the natural process of breaking down and reabsorbing bones. omega atsumu Other Warnings: Patients undergoing treatment with Prolia are at risk of experiencing the following serious complications: The most common side effects of Prolia® in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection. 2%) compared to women treated with Prolia® (2 Study consisted of 7393 patients who received either Prolia® or a placebo (a treatment containing no medicine). Product recalls can be a nightmare for both consumers and manufacturers. Despite all the horrible side effects, this last point really sums up Prolia's list of pros and cons. For Osteoporosis "Prolia, for me, it was a nightmare. Immediately after the extraction it’s important to keep biting on the gauze for 20 minutes or longer to ensure it clots well. Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma or cancer bone metastases. Peanut butter is a staple in many households, but recent recalls have left consumers wondering if their favorite brand is safe to eat. The osteoporosis drug’s black box warning follows an FDA review of Centers for Medicare & … The U Food and Drug Administration (FDA) has issued a black box warning — reserved for the most serious safety issues — for the osteoporosis drug denosumab, sold … Personal injury lawyers recently filed a Prolia class-action lawsuit against Amgen, the manufacturer of the drug. Jif peanut butter, a popular brand, has been. Check with your doctor right away if you have blistering, crusting, irritation, itching, or reddening of the skin, cracked, dry, or scaly skin, rash, or swollen skin. The products contain a toxic chemical and you should stop using them right away (obviously). We all know that having a good memory is important for success in life, but do you know how your memory measures up? Take this quick memory test to find out. Evenity has a boxed warning* about the risk of heart attack, stroke, or death due to cardiovascular (heart and blood vessel) problems. It is given as an injection every six months.
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pain in your arms or legs. Are you tired of forgetting important information or struggling to recall details? If so, incorporating memory games into your routine may be the solution you need As a responsible vehicle owner, it is crucial to stay updated on any recalls that may affect your vehicle. Sadly, the drug has caused some unexpected and shocking side effects for consumers. Denosumab may be an option if a woman cannot tolerate bisphosphonates gastrointestinal problems, such as trouble swallowing, inflammation of the esophagus, and ulcers; osteonecrosis (death of bone tissue. 63†,‡ per injection every six months. Feb 23, 2023 · There’s no specific recommendations for avoiding Prolia if you have kidney problems. Skin problems • Skin problems may happen if you take Prolia® • Symptoms of skin problems include: – Dermatitis (redness, itching) – Eczema (leathery dry skin, blisters that ooze or become crusty, skin peeling) Thigh bone fracture Call your doctor right away if you think you may be having any of these side effects. One important way to stay updated. Denosumab (Prolia) Prolia (denosumab) is a biologic medicine used to treat and prevent thinning of the bones (called osteoporosis) and other diseases where loss of bone mass is a concern. Taste disorders can create problems for those who need to manage conditions such as heart disease, diabetes, or hypertension. Jan 11, 2021 · Prolia is the brand name for the generic drug denosumab. In a 3-year study, women not treated with Prolia® had more new spine fractures (7. Maybe they were on to something. Risk factors include smoking, old age, poor oral hygiene, invasive dental procedures (including tooth. (RTTNews) - J&M Foods is recal. FDA is investigating the risk of severe hypocalcemia with serious outcomes, including hospitalization and death, in patients with advanced kidney disease on dialysis treated with the osteoporosis. In patients with advanced chronic kidney disease, treatment with Prolia (denosumab) increases the risk of severe hypocalcemia, according to an updated FDA safety alert. Sandoz drugs Jubbonti and Wyost are approved for use in all indications covered by the Amgen products, Prolia and Xgeva. Talk to your insurance provider. This typically takes 2 to 5 years. harry potter disowned by parents wbwl fanfiction hermione It is important that you tell all of your doctors that you are receiving denosumab injection, including your dentist. Prolia is a type of protein called a monoclonal antibody that works by disrupting a natural process in the body that breaks down the bones. If you recall, Prolia is administered as an every six months injection. Had non traumatic t4-7 vertebrae collapse. Prolia is given as 60 mg once every six months in the stomach area, upper arm, or upper leg. The thought of it is terrifying. Jun 27, 2024 · The list price for Prolia® is $1,736. This has changed how we think about bone loss and ways to treat osteoporosis. But people with severe kidney disease or who receive dialysis are at a greater risk for hypocalcemia while taking Prolia. Jan 24, 2024 · Reclast is a bisphosphonate, and Prolia is a monoclonal antibody. There is also a higher chance of developing endocarditis (an infection of the heart's inner lining, usually involving the heart. However, rebound hypercalcemia. The list price for Prolia® is $1,736. tattoo patches This is not a list of all drugs or health problems that interact with denosumab injection (prolia). In today’s fast-paced world, it’s crucial to stay informed about product recalls and take necessary steps to ensure the safety of our households. The controversy over bone drugs Susan E When conventional doctors diagnose a woman as having osteoporosis or osteopenia, they are likely to prescribe so-called bone-building drugs like Fosamax, Reclast, Forteo, Evenity, Tymols or Prolia. Denosumab may cause low calcium levels, especially if you have kidney problems. Skin problems may occur after receiving Prolia®. I had to stop the Prolia because I needed four teeth removed within 6 months after trying root canals that failed and then had two dental implants. The service, available to GP practices, is a simple and effective solution to manage multiple patients on denosumab who are due their injection at different times. Prolia (also known as Denosumab) is a drug used in the treatment of osteoporosis. This medication guide provides information about the Prolia brand of denosumab. Amgen and UCB's osteoporosis drug Evenity has finally won over the FDA, thanks to a pared-back indication in high-risk women. This article will explain some similarities and differences between Reclast and Prolia, including uses, side effects, interactions, and how each drug works. Two months after the injection I noticed jaw pain. I would like to invite @ritafarmer, @mabel343, @kenzreggie, @bonnieh218, and @tessie to share any side-effects they, or a loved one, had or didn't have while taking Prolia. One of their key functions is to identify and address veh. motorcycle trader houston Skin problems may occur after receiving Prolia®. Prolia: Denosumab belongs to a family of medications known as monoclonal antibodies. If you own a Jeep or are planning to buy one, it’s important to be aware of any potential recalls that may affect your vehicle. But they each work differently because Prolia is a monoclonal antibody (it may also be called a miscellaneous bone resorption agent) and Reclast is a bisphosphonate which means they have different side effects, other uses, tolerability, and effectiveness profiles. lump or swelling in the abdomen or stomach. 63†,‡ per injection every six months. Prolia was first promoted as an osteoporosis treatment by the drugmaker Amgen. Osteonecrosis of the jaw is a well-known and common side-effect in patients receiving denosumab 120 mg for cancer. Rare but serious Prolia side effects are also possible, including: A higher risk of serious infections. Elective Orthopedic Surgery timing is the same. Prolia was later approved to increase bone mass in men with. Prolia is available as a solution for injection in prefilled syringes, each containing 60 mg denosumab. 4 injections) and have had no side effects. While it has proven effective for some, the drug has also been the subject of controversy due to its potentially harmful side effects.
• have an increased risk for fractures (broken bones). Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems. Diagnosed w osteoporosis at age 50 (I'm 72now). Prolia was first promoted as an osteoporosis treatment by the drugmaker Amgen. quebec lotto 649 Denosumab is a biologic RANKL inhibitor used to treat osteoporosis in men and postmenopausal women. It is important for you to practice good mouth care during treatment with Prolia. • osteonecrosis (death of tissue) in the jawbone The most common side effects of Prolia® in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection. Prolia 60 mg solution for injection in pre-filled syringe - Summary of Product Characteristics (SmPC) by Amgen Ltd Prolia is used for the treatment. I started Prolia in January. Great effort, Lyndall and the Central Pottsville Medical Centre team. Print patient leaflet as text only. Honda is recalling over half a million cars due to corroding parts. amazon msg One of the most effective ways to do this is by conducti. The controversy over bone drugs Susan E When conventional doctors diagnose a woman as having osteoporosis or osteopenia, they are likely to prescribe so-called bone-building drugs like Fosamax, Reclast, Forteo, Evenity, Tymols or Prolia. For Paget's disease, Reclast is given as a single infusion. Thanks for sharing your learningRead more. It is unknown if the long-term use of denosumab time may. 8%, hip fractures by 0. my matterport house Ignoring or neglecting these recalls can have serious consequences, not o. swelling of arms or legs. Prolia can cause side effects that range from mild to serious. Prolia is a prescription drug used to treat or prevent osteoporosis. 9)Suppression of bone turnover: Significant suppressio. One of the most effective ways to do this is by conducti. It can help to strengthen bones, making them less likely to break.
• Prolia®is a medicine that may affect the ability of your body to fight infections • Serious infections in your skin, lower stomach area (abdomen), bladder, or ear may happen if you take Prolia®. Prolia can cause many serious side effects. Prolia (Denusab) is the new drug approved by the FDA to treat osteoporosis patients. When it comes to purchasing a used vehicle, one of the most important things you need to consider is whether the vehicle has any outstanding recalls. A recall is a voluntary action taken by a company to remove a defective drug product from the market or warn patients and consumers about a potential risk. Unrelated to bisphosphonates, denosumab might be used in people who can't take a bisphosphonate, such as some people with reduced kidney function. Amgen Lawsuit: What Everybody Should Know. For more information, please see the “ Prolia and pregnancy ” section above Jun 30, 2023 · Learn about side effects, alternatives, and more of Prolia (denosumab) dental problems and jaw-related side effects, such as jaw pain and an increase in infections; severe allergic reaction* The most common adverse reactions (>5% and more common than placebo) in men with osteoporosis are back pain, arthralgia, and nasopharyngitis. to women treated with Prolia® (2 Study consisted of 7393 patients who received either Prolia® or a placebo (a treatment containing no medicine). In many cases, Medicare covers Prolia to make treatment more affordable. See Full PI & Safety Info. Check with your doctor right away if you have blistering, crusting, irritation, itching, or reddening of the skin, cracked, dry, or scaly skin, rash, or swollen skin. Jan 11, 2021 · Prolia is the brand name for the generic drug denosumab. It can help to strengthen bones, making them less likely to break. • develop a swollen, red area of skin, most commonly in the lower leg, that feels hot and tender (cellulitis) and sometimes experienced with fever and chills. Honda is recalling over half a million cars due to corroding parts. I've only been on Prolia for 3-1/2 weeks, and I am praying and crossing my fingers that the dermatitis will be the only side effect, as there is a long list of them. In a study of 2,594 adults initiating denosumab for non-cancer indications (Prolia), on-time injections -- defined as administering the subsequent injection within 4 weeks after the recommended. May 16, 2019 · Denosumab is a biologic RANKL inhibitor used to treat osteoporosis in men and postmenopausal women. Weakened bones can lead to fractures. high cholesterol levels *. bladder or urinary. sucess leasing Unrelated to bisphosphonates, denosumab might be used in people who can't take a bisphosphonate, such as some people with reduced kidney function. The New Zealand data sheet includes warnings on the risk of skin infections, such as cellulitis [ 1 ]. 2%) compared to women treated with Prolia® (2 Study consisted of 7393 patients who received either Prolia® or a placebo (a treatment containing no medicine). Advertisement No, it isn't jus. Women taking Prolia® for 3 years reduced their risk of new spine fractures by 68%. dimpling of the breast skin inverted nipple. Prolia is a brand (trade) name for denosumab which may be used to treat osteoporosis Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. If you have questions about Prolia® (denosumab) and would like to speak to a representative, please call 1‑877‑4‑PROLIA (877‑477‑6542). The most common side effects of Prolia® in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). Prolia is an expensive method of preventing osteoporotic hip fractures, and is associated with significant adverse effects. Post-menopausal bone loss is not a disease; it's simply a change in body chemistry that requires. The risk is greater with decreased kidney function, and health care providers are advised to use cautiously in these cases. Provide each patient with a Medication Guide every time you administer Prolia to your patients as the information contained within may change over time. The gluten found in the testing was between 20 ppm and 50 ppm. I started Prolia in January. 3%, and nonvertebral fractures by 1 Prolia® is the result of recent thinking in bone science. VinFast has issued its first recall for some 2023 VF8 vehicles over a software glitch that causes the dashboard screen to go blank. A recent bone density test showed I have significant bone loss in parts of my body. osd sidekick not working muscle or joint pain. I have severe osteoporosis and finally agreed to Prolia. Have you ever found yourself humming a catchy tune or trying to recall the lyrics of a song that’s stuck in your head? We’ve all been there. Xgeva (denosumab): Uses, Side Effects, Dosage & Reviews. The medicine is also approved to increase bone mass in men receiving androgen deprivation therapy for prostate cancer who are at high. 3% in the placebo group and 4. Denosumab (Prolia) is a monoclonal antibody given as a twice-yearly injection. I would like to invite @ritafarmer, @mabel343, @kenzreggie, @bonnieh218, and @tessie to share any side-effects they, or a loved one, had or didn't have while taking Prolia. Prolia (denosumab) The Indications, Warnings and Precautions, Adverse Reactions (Post-Market Adverse Reactions), Clinical Pharmacology (Pharmacokinetics, Special Populations and Conditions), and Patient Medication Information sections of the Canadian product monograph for Prolia have been updated with additional information on the risk of. Prolia is a medicine that may affect the ability of your body to fight infections. Fractures are painful and restrict a person's ability to carry out their normal daily tasks. Prolia (denosumab) is a convenient option for treating osteoporosis because you only need one dose of the medication every 6 months. These notices may include a list of possible medication recalls, market withdrawals, alerts and warnings. Symptoms may include jaw pain, loose teeth, jaw bone enlargement, red gums and gum ulcers. I decided to quit Prolia before the 4th shot and started on weekly Alendronate in Jan 2024. The most common side effects of Prolia® in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). I have had hair loss, extreme weight loss, exhaustion, depression & anxiety , blood pressure extreme highs & lows , labored breathing w/ chest pain causing me to have a stress test & echocardiogram. However, this medication can cause a decrease in calcium (hypocalcemia), sometimes severely. Includes: indications, dosage, adverse reactions and pharmacology. Prolia is contraindicated in: Patients with hypocalcemia: Pre-existing hypocalcemia must be corrected prior to initiating therapy with Prolia [see Warnings and Precautions (5 Prolia, a medication developed by Amgen, is prescribed for the treatment of osteoporosis in postmenopausal women. Specifically, it inhibits a protein that your body uses to signal for removing old bone tissue. I tried Fosamax, but my body wouldn't tolerate it. PROLIA - the dental significance.